InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CEP290

Summary

InnateDB Gene

IDBG-630538.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CEP290

Gene Name

centrosomal protein of 290 kDa

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018745

Encoded Proteins

IDBP-682100

centrosomal protein of 290 kDa

IDBP-682148

centrosomal protein of 290 kDa

IDBP-682155

centrosomal protein of 290 kDa

IDBP-682158

centrosomal protein of 290 kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198707:
This gene encodes a protein with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in this gene have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:17902277-17998418

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000024961	ENSBTAP00000024961
ENSBTAT00000005450	ENSBTAP00000005450
ENSBTAT00000063396	ENSBTAP00000054733
ENSBTAT00000065117	ENSBTAP00000055652

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007163	establishment or maintenance of cell polarity
GO:0015031	protein transport
GO:0030814	regulation of cAMP metabolic process
GO:0042384	cilium assembly
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060041	retina development in camera-type eye
GO:0060271	cilium morphogenesis
GO:0070201	regulation of establishment of protein localization
GO:0090316	positive regulation of intracellular protein transport

Cellular Component

GO:0000930	gamma-tubulin complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0032391	photoreceptor connecting cilium
GO:0034451	centriolar satellite
GO:0036038	TCTN-B9D complex
GO:0043234	protein complex