InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CCL3

Summary

InnateDB Gene

IDBG-630569.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCL3

Gene Name

C-C motif chemokine 3 precursor

Synonyms

CCL3L1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000025250

Encoded Proteins

IDBP-682028

C-C motif chemokine 3 precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The human genome reference assembly contains two full copies of the gene (CCL3L3 and CCL3L1) and a partial pseudogene. This record represents the more centromeric full-length gene. [provided by RefSeq, Apr 2010] This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The human genome reference assembly contains two full copies of the gene (CCL3L3 and CCL3L1) and a partial pseudogene. This record represents the more telomeric full-length gene. [provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:14673890-14675910

Strand

Forward strand

Band

Transcripts

ENSBTAT00000035430

ENSBTAP00000035305

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008009	chemokine activity

Biological Process

GO:0006955	immune response
GO:0008360	regulation of cell shape
GO:0032760	positive regulation of tumor necrosis factor production
GO:0043525	positive regulation of neuron apoptotic process
GO:0043615	astrocyte cell migration
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048246	macrophage chemotaxis
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050729	positive regulation of inflammatory response