Version 5.4
Mus musculus Gene: Ccl3
Summary
InnateDB Gene IDBG-205582.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccl3
Gene Name chemokine (C-C motif) ligand 3
Synonyms AI323804; G0S19-1; LD78alpha; MIP-1alpha; MIP1-(a); MIP1-alpha; Mip1a; Scya3
Species Mus musculus
Ensembl Gene ENSMUSG00000000982
Encoded Proteins
IDBP-205584
chemokine (C-C motif) ligand 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The human genome reference assembly contains two full copies of the gene (CCL3L3 and CCL3L1) and a partial pseudogene. This record represents the more centromeric full-length gene. [provided by RefSeq, Apr 2010] This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein binds to several chemokine receptors including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than six copies. The human genome reference assembly contains two full copies of the gene (CCL3L3 and CCL3L1) and a partial pseudogene. This record represents the more telomeric full-length gene. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:83647844-83649355
Strand Reverse strand
Band C
Transcripts
ENSMUST00000001008 ENSMUSP00000001008
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 8 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005515 protein binding
GO:0008009 chemokine activity
GO:0016004 phospholipase activator activity
GO:0016301 kinase activity
GO:0042056 chemoattractant activity
Biological Process
GO:0000165 MAPK cascade
GO:0001649 osteoblast differentiation
GO:0001775 cell activation
GO:0002548 monocyte chemotaxis
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006887 exocytosis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007010 cytoskeleton organization
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007610 behavior
GO:0008360 regulation of cell shape
GO:0009636 response to toxic substance
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010818 T cell chemotaxis
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019722 calcium-mediated signaling
GO:0023052 signaling
GO:0030335 positive regulation of cell migration
GO:0030593 neutrophil chemotaxis
GO:0030595 leukocyte chemotaxis
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042493 response to drug
GO:0043085 positive regulation of catalytic activity
GO:0043308 eosinophil degranulation
GO:0043491 protein kinase B signaling
GO:0043525 positive regulation of neuron apoptotic process
GO:0043615 astrocyte cell migration
GO:0043922 negative regulation by host of viral transcription
GO:0045671 negative regulation of osteoclast differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048245 eosinophil chemotaxis
GO:0048246 macrophage chemotaxis
GO:0048247 lymphocyte chemotaxis
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050729 positive regulation of inflammatory response
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050918 positive chemotaxis
GO:0051928 positive regulation of calcium ion transport
GO:0051930 regulation of sensory perception of pain
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070723 response to cholesterol
GO:0071407 cellular response to organic cyclic compound
GO:0071621 granulocyte chemotaxis
GO:2000503 positive regulation of natural killer cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
null
View Gene Order
ENSBTAG00000025250
Not yet available
Pathways
NETPATH
REACTOME
REACT_254215
Signaling by GPCR pathway
REACT_261161
Class A/1 (Rhodopsin-like receptors) pathway
REACT_231468
GPCR ligand binding pathway
REACT_235286
Peptide ligand-binding receptors pathway
REACT_230248
Chemokine receptors bind chemokines pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04620
Toll-like receptor signaling pathway pathway
mmu04062
Chemokine signaling pathway pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
PID NCI
Cross-References
SwissProt P10855
TrEMBL Q5QNW0
UniProt Splice Variant
Entrez Gene 20302
UniGene
RefSeq NM_011337
OMIM
CCDS CCDS36255
HPRD
IMGT
MGI ID MGI:98260
MGI Symbol Ccl3
EMBL AF065939 AF065940 AF065941 AF065942 AF065943 AK150590 AK150634 AK150698 AK151581 AK152648 BC111443 CH466556 EU366956 J04491 M23447 M73061 X12531 X53372
GenPept AAA39707 AAA40146 AAA40304 AAC17506 AAC17507 AAC17508 AAC17509 AAC17510 AAI11444 ABY66390 BAE29684 BAE29723 BAE29777 BAE30521 BAE31386 CAA31047 CAA37452 EDL15715
RNA Seq Atlas 20302

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca