InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: AIFM1

Summary

InnateDB Gene

IDBG-630636.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AIFM1

Gene Name

apoptosis-inducing factor 1, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006838

Encoded Proteins

IDBP-682117

apoptosis-inducing factor, mitochondrion-associated, 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156709:
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:13966656-13997438

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000008987

ENSBTAP00000008987

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.

Predicted by orthology
Total	56 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0016174	NAD(P)H oxidase activity
GO:0016491	oxidoreductase activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H
GO:0046983	protein dimerization activity
GO:0050660	flavin adenine dinucleotide binding
GO:0071949	FAD binding

Biological Process

GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010942	positive regulation of cell death
GO:0030182	neuron differentiation
GO:0032981	mitochondrial respiratory chain complex I assembly
GO:0045454	cell redox homeostasis
GO:0051402	neuron apoptotic process
GO:0055114	oxidation-reduction process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:1902510	regulation of apoptotic DNA fragmentation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000156709

View Gene Order

ENSMUSG00000036932

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04210

Apoptosis pathway

mmu04210

Apoptosis pathway

INOH

PID NCI

ceramide_pathway

Ceramide signaling pathway

Cross-References

SwissProt

TrEMBL

E1BJA2

UniProt Splice Variant

Entrez Gene

535714

UniGene

Bt.11337

RefSeq

NM_001192984

HUGO

HGNC:8768

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02067453

GenPept

RNA Seq Atlas

535714