InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATP1A2

Summary

InnateDB Gene

IDBG-630649.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP1A2

Gene Name

Sodium/potassium-transporting ATPase subunit alpha-2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010551

Encoded Proteins

IDBP-682120

Sodium/potassium-transporting ATPase subunit alpha-2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000018625:
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:9645440-9670496

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000049161

ENSBTAP00000046095

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015077	monovalent inorganic cation transmembrane transporter activity
GO:0016787	hydrolase activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829	cation-transporting ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0001504	neurotransmitter uptake
GO:0002026	regulation of the force of heart contraction
GO:0002087	regulation of respiratory gaseous exchange by neurological system process
GO:0006754	ATP biosynthetic process
GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0006937	regulation of muscle contraction
GO:0006940	regulation of smooth muscle contraction
GO:0006942	regulation of striated muscle contraction
GO:0008217	regulation of blood pressure
GO:0008344	adult locomotory behavior
GO:0008542	visual learning
GO:0015672	monovalent inorganic cation transport
GO:0019229	regulation of vasoconstriction
GO:0035725	sodium ion transmembrane transport
GO:0040011	locomotion
GO:0045822	negative regulation of heart contraction
GO:0045988	negative regulation of striated muscle contraction
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0055085	transmembrane transport