Version 5.4
Homo sapiens Gene: ATP1A2
Summary
InnateDB Gene IDBG-103993.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP1A2
Gene Name ATPase, Na+/K+ transporting, alpha 2 polypeptide
Synonyms FHM2; MHP2
Species Homo sapiens
Ensembl Gene ENSG00000018625
Encoded Proteins
IDBP-103995
ATPase, Na+/K+ transporting, alpha 2 polypeptide
IDBP-246076
ATPase, Na+/K+ transporting, alpha 2 polypeptide
IDBP-389228
ATPase, Na+/K+ transporting, alpha 2 polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:160115759-160143591
Strand Forward strand
Band q23.2
Transcripts
ENST00000361216 ENSP00000354490
ENST00000392233 ENSP00000376066
ENST00000447527 ENSP00000411705
ENST00000472488
ENST00000478587
ENST00000468587
ENST00000463989
ENST00000459972
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005391 sodium:potassium-exchanging ATPase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0019829 cation-transporting ATPase activity
GO:0046872 metal ion binding
Biological Process
GO:0001504 neurotransmitter uptake
GO:0002026 regulation of the force of heart contraction
GO:0002087 regulation of respiratory gaseous exchange by neurological system process
GO:0006754 ATP biosynthetic process
GO:0006812 cation transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006937 regulation of muscle contraction
GO:0006940 regulation of smooth muscle contraction
GO:0006942 regulation of striated muscle contraction
GO:0008217 regulation of blood pressure
GO:0008344 adult locomotory behavior
GO:0008542 visual learning
GO:0015672 monovalent inorganic cation transport
GO:0015991 ATP hydrolysis coupled proton transport
GO:0019229 regulation of vasoconstriction
GO:0034220 ion transmembrane transport
GO:0035094 response to nicotine
GO:0035725 sodium ion transmembrane transport
GO:0040011 locomotion
GO:0045822 negative regulation of heart contraction
GO:0045988 negative regulation of striated muscle contraction
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0055085 transmembrane transport
GO:0071260 cellular response to mechanical stimulus
GO:0086004 regulation of cardiac muscle cell contraction
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0005901 caveola
GO:0016021 integral component of membrane
GO:0030315 T-tubule
GO:0042383 sarcolemma
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000007097
View Gene Order
ENSBTAG00000010551
Not yet available
Pathways
NETPATH
REACTOME
REACT_25149
Ion transport by P-type ATPases pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
hsa04260
Cardiac muscle contraction pathway
hsa04960
Aldosterone-regulated sodium reabsorption pathway
hsa04964
Proximal tubule bicarbonate reclamation pathway
hsa04971
Gastric acid secretion pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
hsa04976
Bile secretion pathway
hsa04974
Protein digestion and absorption pathway
hsa04973
Carbohydrate digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.34114
RefSeq NM_000702
HUGO
OMIM
CCDS CCDS1196
HPRD 01665
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca