InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KCNMA1

Summary

InnateDB Gene

IDBG-630746.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNMA1

Gene Name

Calcium-activated potassium channel subunit alpha-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013300

Encoded Proteins

IDBP-682257

Calcium-activated potassium channel subunit alpha-1

IDBP-682261

Calcium-activated potassium channel subunit alpha-1

IDBP-682263

Calcium-activated potassium channel subunit alpha-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156113:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:32807351-33587986

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017701	ENSBTAP00000017701
ENSBTAT00000017697	ENSBTAP00000017697
ENSBTAT00000054334	ENSBTAP00000047743

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005216	ion channel activity
GO:0005244	voltage-gated ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0015269	calcium-activated potassium channel activity
GO:0046872	metal ion binding
GO:0060072	large conductance calcium-activated potassium channel activity

Biological Process

GO:0001666	response to hypoxia
GO:0006810	transport
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0006970	response to osmotic stress
GO:0030007	cellular potassium ion homeostasis
GO:0034465	response to carbon monoxide
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0043065	positive regulation of apoptotic process
GO:0045794	negative regulation of cell volume
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport
GO:0060073	micturition
GO:0060083	smooth muscle contraction involved in micturition
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005901	caveola
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome