Version 5.4
Homo sapiens Gene: KCNMA1
Summary
InnateDB Gene IDBG-79612.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNMA1
Gene Name potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms bA205K10.1; BKTM; KCa1.1; MaxiK; mSLO1; SAKCA; SLO; SLO-ALPHA; SLO1
Species Homo sapiens
Ensembl Gene ENSG00000156113
Encoded Proteins
IDBP-79614
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-79616
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-79618
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-79622
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-79630
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-79632
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-79634
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-79636
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-79638
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-295420
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-295416
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-295413
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-380902
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-380916
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-380947
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-380950
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-811348
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-811349
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-811333
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
IDBP-811353
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:76869601-77638595
Strand Reverse strand
Band q22.3
Transcripts
ENST00000372443 ENSP00000361520
ENST00000372440 ENSP00000361517
ENST00000372437 ENSP00000361514
ENST00000286628 ENSP00000286628
ENST00000286627 ENSP00000286627
ENST00000372421 ENSP00000361498
ENST00000372408 ENSP00000361485
ENST00000372403 ENSP00000361480
ENST00000354353 ENSP00000346321
ENST00000404771 ENSP00000385717
ENST00000404857 ENSP00000385806
ENST00000406533 ENSP00000385552
ENST00000457953 ENSP00000396608
ENST00000434208 ENSP00000402150
ENST00000450795 ENSP00000388370
ENST00000428546 ENSP00000402254
ENST00000468471
ENST00000475352
ENST00000484507
ENST00000484343
ENST00000481070 ENSP00000475086
ENST00000480683 ENSP00000474686
ENST00000604624 ENSP00000473714
ENST00000618048 ENSP00000482747
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding
GO:0015269 calcium-activated potassium channel activity
GO:0046872 metal ion binding
GO:0060072 large conductance calcium-activated potassium channel activity
Biological Process
GO:0001666 response to hypoxia
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0006970 response to osmotic stress
GO:0007268 synaptic transmission
GO:0007596 blood coagulation
GO:0030007 cellular potassium ion homeostasis
GO:0034465 response to carbon monoxide
GO:0034765 regulation of ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0043065 positive regulation of apoptotic process
GO:0045794 negative regulation of cell volume
GO:0051592 response to calcium ion
GO:0055085 transmembrane transport
GO:0060073 micturition
GO:0060083 smooth muscle contraction involved in micturition
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063142
View Gene Order
ENSBTAG00000013300
Not yet available
Pathways
NETPATH
REACTOME
REACT_23767
cGMP effects pathway
REACT_23862
Nitric oxide stimulates guanylate cyclase pathway
REACT_23876
Platelet homeostasis pathway
REACT_75896
Ca2+ activated K+ channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
REACT_604
Hemostasis pathway
KEGG
hsa04270
Vascular smooth muscle contraction pathway
hsa04972
Pancreatic secretion pathway
hsa04970
Salivary secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.144795
RefSeq NM_001014797 NM_001161352 NM_001161353 NM_001271518 NM_001271519 NM_001271520 NM_001271521 NM_001271522 NM_002247 XM_005269795 XM_005269796 XM_005269797 XM_006717826
HUGO
OMIM
CCDS CCDS60569 CCDS60571 CCDS60572 CCDS73156 CCDS7352
HPRD 15967
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca