Version 5.4
Homo sapiens Gene: GMPR
Summary
InnateDB Gene IDBG-63076.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GMPR
Gene Name guanosine monophosphate reductase
Synonyms GMPR1
Species Homo sapiens
Ensembl Gene ENSG00000137198
Encoded Proteins
IDBP-63078
guanosine monophosphate reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. The protein also functions in the re-utilization of free intracellular bases and purine nucleosides.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:16238580-16295549
Strand Forward strand
Band p22.3
Transcripts
ENST00000259727 ENSP00000259727
ENST00000543191
ENST00000544145
ENST00000540478
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003920 GMP reductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006144 purine nucleobase metabolic process
GO:0009117 nucleotide metabolic process
GO:0009409 response to cold
GO:0043101 purine-containing compound salvage
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
GO:1902560 GMP reductase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000253
View Gene Order
ENSBTAG00000015743
Not yet available
Pathways
NETPATH
REACTOME
REACT_1923
Purine salvage pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt P36959
TrEMBL
UniProt Splice Variant
Entrez Gene 2766
UniGene Hs.484741
RefSeq NM_006877
HUGO HGNC:4376
OMIM 139265
CCDS CCDS4537
HPRD
IMGT
EMBL AL009031 AL138883 BC008281 L35304 M24470 M27941
GenPept AAA52498 AAA52503 AAA53106 AAH08281 CAI19917 CAI21422
RNA Seq Atlas 2766

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca