Version 5.4
| Bos taurus Gene: IL18R1 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-630853.3 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | IL18R1 | ||||||||||||
| Gene Name | Uncharacterized protein | ||||||||||||
| Synonyms | IL-18Ra | ||||||||||||
| Species | Bos taurus | ||||||||||||
| Ensembl Gene | ENSBTAG00000001034 | ||||||||||||
| Encoded Proteins |
interleukin 18 receptor 1
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| Protein Structure | |||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||
| Summary |
[Homo sapiens] IL37 acts as an extracellular cytokine to inhibit innate inflammation by binding to IL18R1 and then using IL1RAPL1 for its anti-inflammatory properties.
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| Entrez Gene | |||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115604:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 11:7153231-7179569 | ||||||||||||
| Strand | Forward strand | ||||||||||||
| Band | |||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME | |||||||||||||
| KEGG |
Cytokine-cytokine receptor interaction pathway
Cytokine-cytokine receptor interaction pathway
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| INOH |
JAK STAT pathway and regulation pathway
JAK STAT pathway and regulation pathway
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| PID NCI |
IL12-mediated signaling events
IL12 signaling mediated by STAT4
IL23-mediated signaling events
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| Cross-References | |||||||||||||
| SwissProt | |||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | |||||||||||||
| UniGene | Bt.29883 | ||||||||||||
| RefSeq | XM_002691182 XM_005193845 XM_005193846 XM_005193847 XM_005193848 XM_005212458 XM_005212459 XM_005212460 XM_005212461 XM_590497 | ||||||||||||
| HUGO | |||||||||||||
| OMIM | |||||||||||||
| CCDS | |||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | |||||||||||||
| GenPept | |||||||||||||
| RNA Seq Atlas | |||||||||||||