Bos taurus Gene: TREM2
Summary
InnateDB Gene IDBG-630863.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TREM2
Gene Name triggering receptor expressed on myeloid cells 2 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000007275
Encoded Proteins
triggering receptor expressed on myeloid cells 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] TREM2 inhibits the induction of inflammatory cytokines and type I IFN production in TLR-stimulated dendritic cells. (Demonstrated in mice)
[Mus musculus] Trem2 inhibits the induction of inflammatory cytokines and type I IFN production in TLR-stimulated dendritic cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095970:
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:15090107-15094736
Strand Reverse strand
Band
Transcripts
ENSBTAT00000009568 ENSBTAP00000009568
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0005515 protein binding
GO:0097110 scaffold protein binding
Biological Process
GO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0097028 dendritic cell differentiation
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903082 positive regulation of C-C chemokine receptor CCR7 signaling pathway
GO:2000350 positive regulation of CD40 signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
RANKL pathway
REACTOME
DAP12 signaling pathway
DAP12 interactions pathway
Other semaphorin interactions pathway
Developmental Biology pathway
Semaphorin interactions pathway
Innate Immune System pathway
Axon guidance pathway
Immune System pathway
Innate Immune System pathway
Immune System pathway
Axon guidance pathway
Developmental Biology pathway
Semaphorin interactions pathway
Other semaphorin interactions pathway
DAP12 interactions pathway
DAP12 signaling pathway
KEGG
Osteoclast differentiation pathway
Osteoclast differentiation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q05B59
UniProt Splice Variant
Entrez Gene 506467
UniGene Bt.45563
RefSeq NM_001079580
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC122771 DAAA02055058
GenPept AAI22772
RNA Seq Atlas 506467