Bos taurus Gene: TREM2 | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||
InnateDB Gene | IDBG-630863.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | TREM2 | ||||||||||||||||
Gene Name | triggering receptor expressed on myeloid cells 2 precursor | ||||||||||||||||
Synonyms | |||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000007275 | ||||||||||||||||
Encoded Proteins |
triggering receptor expressed on myeloid cells 2
|
||||||||||||||||
Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||
Summary |
[Homo sapiens] TREM2 inhibits the induction of inflammatory cytokines and type I IFN production in TLR-stimulated dendritic cells. (Demonstrated in mice)
[Mus musculus] Trem2 inhibits the induction of inflammatory cytokines and type I IFN production in TLR-stimulated dendritic cells.
|
||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095970:
This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012] |
||||||||||||||||
Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 23:15090107-15094736 | ||||||||||||||||
Strand | Reverse strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
|
||||||||||||||||
Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|
||||||||||||||||
Gene Ontology | |||||||||||||||||
Molecular Function |
|
||||||||||||||||
Biological Process |
|
||||||||||||||||
Cellular Component |
|
||||||||||||||||
Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH |
RANKL pathway
|
||||||||||||||||
REACTOME |
DAP12 signaling pathway
DAP12 interactions pathway
Other semaphorin interactions pathway
Developmental Biology pathway
Semaphorin interactions pathway
Innate Immune System pathway
Axon guidance pathway
Immune System pathway
Innate Immune System pathway
Immune System pathway
Axon guidance pathway
Developmental Biology pathway
Semaphorin interactions pathway
Other semaphorin interactions pathway
DAP12 interactions pathway
DAP12 signaling pathway
|
||||||||||||||||
KEGG |
Osteoclast differentiation pathway
Osteoclast differentiation pathway
|
||||||||||||||||
INOH | |||||||||||||||||
PID NCI | |||||||||||||||||
Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | Q05B59 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 506467 | ||||||||||||||||
UniGene | Bt.45563 | ||||||||||||||||
RefSeq | NM_001079580 | ||||||||||||||||
HUGO | |||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | BC122771 DAAA02055058 | ||||||||||||||||
GenPept | AAI22772 | ||||||||||||||||
RNA Seq Atlas | 506467 | ||||||||||||||||