InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PCSK7

Summary

InnateDB Gene

IDBG-630871.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCSK7

Gene Name

proprotein convertase subtilisin/kexin type 7

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003052

Encoded Proteins

IDBP-682367

proprotein convertase subtilisin/kexin type 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160613:
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Jul 2008]
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:28323768-28351207

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000040088

ENSBTAP00000039868

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004252	serine-type endopeptidase activity
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0016485	protein processing

Cellular Component

GO:0030173

integral component of Golgi membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000160613

View Gene Order

ENSMUSG00000035382

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_248921

Signalling by NGF pathway

REACT_188257

Signal Transduction pathway

REACT_206713

NGF processing pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.62043

RefSeq

NM_001192978 XM_005215839

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas