Version 5.4
Homo sapiens Gene: PCSK7
Summary
InnateDB Gene IDBG-73097.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCSK7
Gene Name proprotein convertase subtilisin/kexin type 7
Synonyms LPC; PC7; PC8; SPC7
Species Homo sapiens
Ensembl Gene ENSG00000160613
Encoded Proteins
IDBP-73101
proprotein convertase subtilisin/kexin type 7
IDBP-586661
proprotein convertase subtilisin/kexin type 7
IDBP-591730
proprotein convertase subtilisin/kexin type 7
IDBP-602420
proprotein convertase subtilisin/kexin type 7
IDBP-590450
proprotein convertase subtilisin/kexin type 7
IDBP-601683
proprotein convertase subtilisin/kexin type 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Jul 2008]
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:117204337-117232525
Strand Reverse strand
Band q23.3
Transcripts
ENST00000320934 ENSP00000325917
ENST00000534529
ENST00000529458
ENST00000527037
ENST00000527861
ENST00000532810
ENST00000531573
ENST00000533135
ENST00000528973
ENST00000528217
ENST00000525027 ENSP00000431181
ENST00000524507 ENSP00000433841
ENST00000532301 ENSP00000436459
ENST00000530269 ENSP00000433252
ENST00000540028 ENSP00000441944
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016485 protein processing
GO:0016486 peptide hormone processing
Cellular Component
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035382
View Gene Order
ENSBTAG00000003052
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.648612 Hs.662895 Hs.684226 Hs.735994
RefSeq NM_004716 XM_006718939 XM_006718940
HUGO
OMIM
CCDS CCDS8382
HPRD 05339
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca