Version 5.4
Bos taurus Gene: IL18RAP
Summary
InnateDB Gene IDBG-630876.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL18RAP
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000033748
Encoded Proteins
IDBP-682378
interleukin 18 receptor accessory protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115607:
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn\'s disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:7196920-7221257
Strand Forward strand
Band
Transcripts
ENSBTAT00000047919 ENSBTAP00000045070
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000115607
View Gene Order
ENSMUSG00000026068
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
mmu04060
Cytokine-cytokine receptor interaction pathway
INOH
PID NCI
il12_2pathway
IL12-mediated signaling events
il12_stat4pathway
IL12 signaling mediated by STAT4
il23pathway
IL23-mediated signaling events
Cross-References
SwissProt
TrEMBL F1MAT8
UniProt Splice Variant
Entrez Gene 493716
UniGene
RefSeq XM_001255518 XM_002691183
HUGO HGNC:5989
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02030252 DAAA02030253 DAAA02030254
GenPept
RNA Seq Atlas 493716

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca