InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.25483

Summary

InnateDB Gene

IDBG-630910.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.25483

Gene Name

DNA ligase 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018689

Encoded Proteins

IDBP-682402

DNA ligase 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005156:
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:15406341-15425809

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000024875

ENSBTAP00000024875

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0006974	cellular response to DNA damage stimulus
GO:0043504	mitochondrial DNA repair
GO:0045910	negative regulation of DNA recombination
GO:0051103	DNA ligation involved in DNA repair
GO:0071897	DNA biosynthetic process