Version 5.4
Mus musculus Gene: Lig3
Summary
InnateDB Gene IDBG-204684.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lig3
Gene Name ligase III, DNA, ATP-dependent
Synonyms D11Wsu78e
Species Mus musculus
Ensembl Gene ENSMUSG00000020697
Encoded Proteins
IDBP-204686
ligase III, DNA, ATP-dependent
IDBP-204688
ligase III, DNA, ATP-dependent
IDBP-204690
ligase III, DNA, ATP-dependent
IDBP-627089
ligase III, DNA, ATP-dependent
IDBP-627085
ligase III, DNA, ATP-dependent
IDBP-627086
ligase III, DNA, ATP-dependent
IDBP-627087
ligase III, DNA, ATP-dependent
IDBP-627090
ligase III, DNA, ATP-dependent
IDBP-627093
ligase III, DNA, ATP-dependent
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005156:
This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:82781108-82804274
Strand Forward strand
Band C
Transcripts
ENSMUST00000092849 ENSMUSP00000090525
ENSMUST00000080461 ENSMUSP00000079317
ENSMUST00000021039 ENSMUSP00000021039
ENSMUST00000131537 ENSMUSP00000133672
ENSMUST00000155818
ENSMUST00000154887
ENSMUST00000172609
ENSMUST00000173347 ENSMUSP00000134300
ENSMUST00000173727 ENSMUSP00000133849
ENSMUST00000173009 ENSMUSP00000133348
ENSMUST00000173722 ENSMUSP00000133805
ENSMUST00000172837 ENSMUSP00000134101
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
Biological Process
GO:0006266 DNA ligation
GO:0006273 lagging strand elongation
GO:0006281 DNA repair
GO:0006288 base-excision repair, DNA ligation
GO:0006289 nucleotide-excision repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0007049 cell cycle
GO:0043504 mitochondrial DNA repair
GO:0045910 negative regulation of DNA recombination
GO:0051103 DNA ligation involved in DNA repair
GO:0051301 cell division
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0000795 synaptonemal complex
GO:0005634 nucleus
GO:0005694 chromosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000005156
View Gene Order
ENSBTAG00000018689
Not yet available
Pathways
NETPATH
REACTOME
REACT_231541
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_245705
Base Excision Repair pathway
REACT_233397
DNA Repair pathway
REACT_250836
Resolution of Abasic Sites (AP sites) pathway
KEGG
mmu03410
Base excision repair pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_933
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_1893
Resolution of Abasic Sites (AP sites) pathway
REACT_1104
Base Excision Repair pathway
REACT_216
DNA Repair pathway
KEGG
hsa03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.277136 Mm.399687 Mm.413071
RefSeq NM_001291245 NM_001291246 NM_001291247 NM_010716 XM_006532347 XM_006532348 XM_006532350 XM_006532353
OMIM
CCDS CCDS25147 CCDS70266
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca