Version 5.4
Bos taurus Gene: MDFI
Summary
InnateDB Gene IDBG-630920.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MDFI
Gene Name myoD family inhibitor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019343
Encoded Proteins
IDBP-682409
MyoD family inhibitor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112559:
This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:15467450-15482249
Strand Forward strand
Band
Transcripts
ENSBTAT00000025763 ENSBTAP00000025763
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 100 interaction(s) predicted by orthology.
Predicted by orthology
Total 100 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0007257 activation of JUN kinase activity
GO:0009950 dorsal/ventral axis specification
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0043392 negative regulation of DNA binding
GO:0048704 embryonic skeletal system morphogenesis
GO:0060707 trophoblast giant cell differentiation
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000112559
View Gene Order
ENSMUSG00000032717
View Gene Order
Cross-References
SwissProt
TrEMBL F1MLU9
UniProt Splice Variant
Entrez Gene 286808
UniGene Bt.13110
RefSeq NM_001205537 XM_005223383
HUGO HGNC:6967
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02055059
GenPept
RNA Seq Atlas 286808

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca