InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BACE1

Summary

InnateDB Gene

IDBG-630931.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BACE1

Gene Name

Beta-secretase 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019365

Encoded Proteins

IDBP-682414

Beta-secretase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186318:
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer\'s disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:28400714-28422342

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000040056

ENSBTAP00000039837

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004175	endopeptidase activity
GO:0004190	aspartic-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0016787	hydrolase activity
GO:0019899	enzyme binding

Biological Process

GO:0006508	proteolysis
GO:0050435	beta-amyloid metabolic process

Cellular Component

GO:0005768	endosome
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000186318

View Gene Order

ENSMUSG00000032086

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05010

Alzheimer's disease pathway

mmu05010

Alzheimer's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.28273

RefSeq

NM_001046531

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas