InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bace1

Summary

InnateDB Gene

IDBG-160173.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bace1

Gene Name

beta-site APP cleaving enzyme 1

Synonyms

C76936

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032086

Encoded Proteins

IDBP-160175

beta-site APP cleaving enzyme 1

IDBP-160177

beta-site APP cleaving enzyme 1

IDBP-531562

beta-site APP cleaving enzyme 1

IDBP-539725

beta-site APP cleaving enzyme 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186318:
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer\'s disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:45838580-45864399

Strand

Forward strand

Band

A5.2

Transcripts

ENSMUST00000078111	ENSMUSP00000077249
ENSMUST00000034591	ENSMUSP00000034591
ENSMUST00000159499	ENSMUSP00000124773
ENSMUST00000162559
ENSMUST00000159970
ENSMUST00000162587	ENSMUSP00000124960

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004175	endopeptidase activity
GO:0004190	aspartic-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0019899	enzyme binding

Biological Process

GO:0006508	proteolysis
GO:0050435	beta-amyloid metabolic process

Cellular Component

GO:0005768	endosome
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0030424	axon
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000186318

View Gene Order

ENSBTAG00000019365

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05010

Alzheimer's disease pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05010

Alzheimer's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.24044 Mm.443998 Mm.471776

RefSeq

NM_001145947 NM_011792

OMIM

CCDS

CCDS23135 CCDS52784

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas