InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FHL2

Summary

InnateDB Gene

IDBG-631011.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FHL2

Gene Name

Four and a half LIM domains protein 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001086

Encoded Proteins

IDBP-682503

Four and a half LIM domains protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115641:
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:9253234-9300671

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001440

ENSBTAP00000001440

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.

Predicted by orthology
Total	72 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001649	osteoblast differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0009725	response to hormone
GO:0043066	negative regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0055014	atrial cardiac muscle cell development
GO:0055015	ventricular cardiac muscle cell development
GO:0060347	heart trabecula formation