Version 5.4
Homo sapiens Gene: FHL2
Summary
InnateDB Gene IDBG-64511.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FHL2
Gene Name four and a half LIM domains 2
Synonyms AAG11; DRAL; FHL-2; SLIM-3; SLIM3
Species Homo sapiens
Ensembl Gene ENSG00000115641
Encoded Proteins
IDBP-64513
four and a half LIM domains 2
IDBP-64515
four and a half LIM domains 2
IDBP-64517
four and a half LIM domains 2
IDBP-243784
four and a half LIM domains 2
IDBP-243786
four and a half LIM domains 2
IDBP-295053
four and a half LIM domains 2
IDBP-295058
four and a half LIM domains 2
IDBP-295055
four and a half LIM domains 2
IDBP-384084
four and a half LIM domains 2
IDBP-384086
four and a half LIM domains 2
IDBP-592613
four and a half LIM domains 2
IDBP-813405
four and a half LIM domains 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:105357712-105438513
Strand Reverse strand
Band q12.2
Transcripts
ENST00000358129 ENSP00000350846
ENST00000322142 ENSP00000322909
ENST00000344213 ENSP00000344266
ENST00000393353 ENSP00000377021
ENST00000393352 ENSP00000377020
ENST00000409177 ENSP00000386892
ENST00000409807 ENSP00000386665
ENST00000408995 ENSP00000386633
ENST00000452732 ENSP00000414872
ENST00000447958 ENSP00000397083
ENST00000530340 ENSP00000433567
ENST00000607522 ENSP00000476199
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 115 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 115 [view]
Protein-Protein 113 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0042802 identical protein binding
GO:0050681 androgen receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001649 osteoblast differentiation
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0009725 response to hormone
GO:0030521 androgen receptor signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0055014 atrial cardiac muscle cell development
GO:0055015 ventricular cardiac muscle cell development
GO:0060347 heart trabecula formation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0030018 Z disc
GO:0031430 M band
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000008136
View Gene Order
ENSBTAG00000001086
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_5
ID pathway
NetPath_21
RANKL pathway
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa04380
Osteoclast differentiation pathway
INOH
PID NCI
ar_pathway
Coregulation of Androgen receptor activity
hdac_classiii_pathway
Signaling events mediated by HDAC Class III
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001039492 NM_001450 NM_201555 NM_201557 XM_005263901 XM_005263902 XM_005263903 XM_005263904 XM_005263906
HUGO
OMIM
CCDS CCDS2070
HPRD 04026
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca