InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.27987

Summary

InnateDB Gene

IDBG-631020.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.27987

Gene Name

Uncharacterized protein

Synonyms

nk1R

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015575

Encoded Proteins

IDBP-682522

Tachikinin receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23365459

[Mus musculus] Agonists of TACR1 promote immunostimulatory dendritic cells by inhibiting IL10 synthesis and secretion.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115353:
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:9467061-9646849

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020684

ENSBTAP00000020684

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004995	tachykinin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007217	tachykinin receptor signaling pathway
GO:0048265	response to pain