InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TACR1

Summary

InnateDB Gene

IDBG-58132.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TACR1

Gene Name

tachykinin receptor 1

Synonyms

NK1R; NKIR; SPR; TAC1R

Species

Homo sapiens

Ensembl Gene

ENSG00000115353

Encoded Proteins

IDBP-58134

tachykinin receptor 1

IDBP-295463

tachykinin receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23365459

[Mus musculus] Agonists of TACR1 promote immunostimulatory dendritic cells by inhibiting IL10 synthesis and secretion.

Entrez Gene

Summary

This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:75046463-75199700

Strand

Reverse strand

Band

p12

Transcripts

ENST00000305249	ENSP00000303522
ENST00000409848	ENSP00000386448
ENST00000497764

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004995	tachykinin receptor activity
GO:0005515	protein binding
GO:0016496	substance P receptor activity

Biological Process

GO:0002118	aggressive behavior
GO:0002526	acute inflammatory response
GO:0002687	positive regulation of leukocyte migration
GO:0003051	angiotensin-mediated drinking behavior
GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007217	tachykinin receptor signaling pathway
GO:0007611	learning or memory
GO:0007616	long-term memory
GO:0008217	regulation of blood pressure
GO:0008306	associative learning
GO:0009408	response to heat
GO:0009582	detection of abiotic stimulus
GO:0009725	response to hormone
GO:0010193	response to ozone
GO:0010634	positive regulation of epithelial cell migration
GO:0010996	response to auditory stimulus
GO:0014070	response to organic cyclic compound
GO:0014910	regulation of smooth muscle cell migration
GO:0032224	positive regulation of synaptic transmission, cholinergic
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0032355	response to estradiol
GO:0032570	response to progesterone
GO:0035094	response to nicotine
GO:0035106	operant conditioning
GO:0035815	positive regulation of renal sodium excretion
GO:0042713	sperm ejaculation
GO:0042755	eating behavior
GO:0043117	positive regulation of vascular permeability
GO:0043278	response to morphine
GO:0045471	response to ethanol
GO:0045760	positive regulation of action potential
GO:0045777	positive regulation of blood pressure
GO:0045778	positive regulation of ossification
GO:0045907	positive regulation of vasoconstriction
GO:0046878	positive regulation of saliva secretion
GO:0046887	positive regulation of hormone secretion
GO:0048265	response to pain
GO:0048266	behavioral response to pain
GO:0048660	regulation of smooth muscle cell proliferation
GO:0050671	positive regulation of lymphocyte proliferation
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051496	positive regulation of stress fiber assembly
GO:0051602	response to electrical stimulus
GO:0060083	smooth muscle contraction involved in micturition
GO:0070474	positive regulation of uterine smooth muscle contraction

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0044297	cell body
GO:0071944	cell periphery