InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.49424

Summary

InnateDB Gene

IDBG-631033.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.49424

Gene Name

methionine aminopeptidase 2

Synonyms

p67; p67eIF2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019944

Encoded Proteins

IDBP-682526

methionine aminopeptidase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111142:
This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:25255494-25286217

Strand

Forward strand

Band

Transcripts

ENSBTAT00000026568

ENSBTAP00000026568

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008235	metalloexopeptidase activity
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0070006	metalloaminopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0016485	protein processing
GO:0018206	peptidyl-methionine modification
GO:0031365	N-terminal protein amino acid modification
GO:0070084	protein initiator methionine removal