InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Metap2

Summary

InnateDB Gene

IDBG-186322.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Metap2

Gene Name

methionine aminopeptidase 2

Synonyms

4930584B20Rik; A930035J23Rik; AI047573; AL024412; Amp2; AU014659; Mnpep; p67; p67eIF2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036112

Encoded Proteins

IDBP-186324

methionine aminopeptidase 2

IDBP-713119

IDBP-712842

IDBP-712960

IDBP-712467

IDBP-714453

IDBP-712788

IDBP-710650

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111142:
This gene is a member of the methionyl aminopeptidase family and encodes a protein that binds 2 cobalt or manganese ions. This protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent protein. Increased expression of this gene is associated with various forms of cancer and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. A pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:93858489-93897093

Strand

Reverse strand

Band

Transcripts

ENSMUST00000047910	ENSMUSP00000048285
ENSMUST00000181470	ENSMUSP00000138050
ENSMUST00000180688	ENSMUSP00000137652
ENSMUST00000181217	ENSMUSP00000138083
ENSMUST00000180840	ENSMUSP00000138006
ENSMUST00000181740
ENSMUST00000181442
ENSMUST00000180392	ENSMUSP00000137681
ENSMUST00000181009
ENSMUST00000181434
ENSMUST00000180739
ENSMUST00000181104
ENSMUST00000180375	ENSMUSP00000137911
ENSMUST00000181091	ENSMUSP00000137904
ENSMUST00000181894
ENSMUST00000181236

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0005515	protein binding
GO:0008235	metalloexopeptidase activity
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0070006	metalloaminopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0008152	metabolic process
GO:0016485	protein processing
GO:0018206	peptidyl-methionine modification
GO:0031365	N-terminal protein amino acid modification
GO:0070084	protein initiator methionine removal