InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.27462

Summary

InnateDB Gene

IDBG-631085.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.27462

Gene Name

integrin alpha-5

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013745

Encoded Proteins

IDBP-682585

integrin alpha-5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161638:
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:25778012-25799053

Strand

Forward strand

Band

Transcripts

ENSBTAT00000018261

ENSBTAP00000018261

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding

Biological Process

GO:0007044	cell-substrate junction assembly
GO:0007155	cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007613	memory
GO:0031589	cell-substrate adhesion
GO:0033631	cell-cell adhesion mediated by integrin
GO:0035313	wound healing, spreading of epidermal cells
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:2000811	negative regulation of anoikis

Cellular Component

GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032587	ruffle membrane
GO:0045202	synapse