InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.55380

Summary

InnateDB Gene

IDBG-631106.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.55380

Gene Name

S-adenosylmethionine synthase isoform type-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005963

Encoded Proteins

IDBP-682609

S-adenosylmethionine synthase isoform type-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151224:
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:35870568-35887533

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000031299

ENSBTAP00000031255

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004478	methionine adenosyltransferase activity
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0046872	metal ion binding