InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SLC9A6

Summary

InnateDB Gene

IDBG-631146.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC9A6

Gene Name

sodium/hydrogen exchanger 6 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009523

Encoded Proteins

IDBP-682655

sodium/hydrogen exchanger 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198689:
This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic mental retardation, Christianson type. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:19608676-19659279

Strand

Forward strand

Band

Transcripts

ENSBTAT00000031526

ENSBTAP00000031479

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015297	antiporter activity
GO:0015299	solute:proton antiporter activity
GO:0015385	sodium:proton antiporter activity

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006814	sodium ion transport
GO:0006885	regulation of pH
GO:0015992	proton transport
GO:0031547	brain-derived neurotrophic factor receptor signaling pathway
GO:0035725	sodium ion transmembrane transport
GO:0048675	axon extension
GO:0048812	neuron projection morphogenesis
GO:0050808	synapse organization
GO:0051386	regulation of neurotrophin TRK receptor signaling pathway
GO:0055085	transmembrane transport
GO:0060996	dendritic spine development
GO:0097484	dendrite extension
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005768	endosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0031410	cytoplasmic vesicle
GO:0031901	early endosome membrane
GO:0043679	axon terminus
GO:0044308	axonal spine
GO:0045202	synapse
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000198689

View Gene Order

ENSMUSG00000060681

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_19314

Sodium/Proton exchangers pathway

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

hsa04260

Cardiac muscle contraction pathway

mmu04260

Cardiac muscle contraction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

A7MB44

UniProt Splice Variant

Entrez Gene

533137

UniGene

Bt.28535

RefSeq

NM_001101146 XM_005227549 XM_005227550

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC151331 DAAA02067738 DAAA02067739

GenPept

AAI51332

RNA Seq Atlas

533137