Version 5.4
Bos taurus Gene: BT.44024
Summary
InnateDB Gene IDBG-631160.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.44024
Gene Name chromobox protein homolog 5
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006246
Encoded Proteins
IDBP-682664
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000094916:
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:25944853-25971390
Strand Forward strand
Band
Transcripts
ENSBTAT00000008198 ENSBTAP00000008198
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 112 interaction(s) predicted by orthology.
Predicted by orthology
Total 112 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0030674 protein binding, bridging
GO:0035064 methylated histone binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0070491 repressing transcription factor binding
Biological Process
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0000118 histone deacetylase complex
GO:0000776 kinetochore
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005720 nuclear heterochromatin
GO:0005730 nucleolus
GO:0010369 chromocenter
GO:0016605 PML body
GO:0017053 transcriptional repressor complex
GO:0035097 histone methyltransferase complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000094916
View Gene Order
ENSMUSG00000009575
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
REACT_224553
Hemostasis pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
KEGG
INOH
PID NCI
e2f_pathway
E2F transcription factor network
aurora_b_pathway
Aurora B signaling
Cross-References
SwissProt
TrEMBL F2Z4J7 Q52T68
UniProt Splice Variant
Entrez Gene 538885
UniGene
RefSeq NM_001193213
HUGO HGNC:1555
OMIM
CCDS
HPRD
IMGT
EMBL AY962101 DAAA02012833
GenPept AAX94036
RNA Seq Atlas 538885

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca