Version 5.4
Bos taurus Gene: SMUG1
Summary
InnateDB Gene IDBG-631162.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMUG1
Gene Name Single-strand selective monofunctional uracil DNA glycosylase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021974
Encoded Proteins
IDBP-682671
Single-strand selective monofunctional uracil DNA glycosylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123415:
This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:26015049-26019918
Strand Forward strand
Band
Transcripts
ENSBTAT00000029297 ENSBTAP00000029297
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004844 uracil DNA N-glycosylase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0017065 single-strand selective uracil DNA N-glycosylase activity
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006974 cellular response to DNA damage stimulus
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000123415
View Gene Order
ENSMUSG00000036061
View Gene Order
Pathways
NETPATH
REACTOME
REACT_205347
Cleavage of the damaged pyrimidine pathway
REACT_219181
Base-Excision Repair, AP Site Formation pathway
REACT_204980
Resolution of Abasic Sites (AP sites) pathway
REACT_203635
Displacement of DNA glycosylase by APE1 pathway
REACT_204262
DNA Repair pathway
REACT_227493
Recognition and association of DNA glycosylase with site containing an affected pyrimidine pathway
REACT_227100
Removal of DNA patch containing abasic residue pathway
REACT_202612
Base Excision Repair pathway
REACT_206866
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_218762
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_211070
Depyrimidination pathway
REACT_218453
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1064
Displacement of DNA glycosylase by APE1 pathway
REACT_1357
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_933
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_2156
Cleavage of the damaged pyrimidine pathway
REACT_2192
Removal of DNA patch containing abasic residue pathway
REACT_1128
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_702
Recognition and association of DNA glycosylase with site containing an affected pyrimidine pathway
REACT_1893
Resolution of Abasic Sites (AP sites) pathway
REACT_1405
Depyrimidination pathway
REACT_1104
Base Excision Repair pathway
REACT_804
Base-Excision Repair, AP Site Formation pathway
REACT_216
DNA Repair pathway
REACT_219627
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway pathway
REACT_220827
Displacement of DNA glycosylase by APE1 pathway
REACT_231541
Resolution of AP sites via the single-nucleotide replacement pathway pathway
REACT_245705
Base Excision Repair pathway
REACT_210016
Base-Excision Repair, AP Site Formation pathway
REACT_227394
Resolution of AP sites via the multiple-nucleotide patch replacement pathway pathway
REACT_206945
Depyrimidination pathway
REACT_233397
DNA Repair pathway
REACT_209262
Cleavage of the damaged pyrimidine pathway
REACT_219337
Removal of DNA patch containing abasic residue pathway
REACT_208690
Recognition and association of DNA glycosylase with site containing an affected pyrimidine pathway
REACT_250836
Resolution of Abasic Sites (AP sites) pathway
KEGG
hsa03410
Base excision repair pathway
mmu03410
Base excision repair pathway
INOH
PID NCI
Cross-References
SwissProt Q59I47
TrEMBL
UniProt Splice Variant
Entrez Gene 539771
UniGene Bt.64531
RefSeq NM_001014958 XM_005206167 XM_005206168 XM_005206169
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB195271 BC148122
GenPept AAI48123 BAD91385
RNA Seq Atlas 539771

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca