InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CD40LG

Summary

InnateDB Gene

IDBG-631246.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD40LG

Gene Name

CD40 ligand CD40 ligand, membrane form CD40 ligand, soluble form

Synonyms

TNFSF5

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017843

Encoded Proteins

IDBP-682794

CD40 ligandCD40 ligand, membrane formCD40 ligand, soluble form

IDBP-682796

CD40 ligandCD40 ligand, membrane formCD40 ligand, soluble form

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102245:
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:20249086-20260907

Strand

Forward strand

Band

Transcripts

ENSBTAT00000063082	ENSBTAP00000056312
ENSBTAT00000023717	ENSBTAP00000023717

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005174	CD40 receptor binding
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0030168	platelet activation
GO:0030183	B cell differentiation
GO:0032735	positive regulation of interleukin-12 production
GO:0042100	B cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0045190	isotype switching
GO:0048305	immunoglobulin secretion
GO:0051023	regulation of immunoglobulin secretion
GO:2000353	positive regulation of endothelial cell apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane