Version 5.4
Mus musculus Gene: Cd40lg
Summary
InnateDB Gene IDBG-147440.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd40lg
Gene Name CD40 ligand
Synonyms CD154; CD40-L; Cd40l; gp39; HIGM1; IGM; IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; TRAP
Species Mus musculus
Ensembl Gene ENSMUSG00000031132
Encoded Proteins
IDBP-147442
CD40 ligand
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102245:
The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:57212143-57224042
Strand Forward strand
Band A6
Transcripts
ENSMUST00000033466 ENSMUSP00000033466
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 0
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005174 CD40 receptor binding
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0030168 platelet activation
GO:0030183 B cell differentiation
GO:0032735 positive regulation of interleukin-12 production
GO:0042100 B cell proliferation
GO:0043066 negative regulation of apoptotic process
GO:0045190 isotype switching
GO:0048305 immunoglobulin secretion
GO:0051023 regulation of immunoglobulin secretion
GO:2000353 positive regulation of endothelial cell apoptotic process
Cellular Component
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102245
View Gene Order
ENSBTAG00000017843
Not yet available
Pathways
NETPATH
REACTOME
REACT_202937
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_230745
Immune System pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04660
T cell receptor signaling pathway pathway
mmu05310
Asthma pathway
mmu05330
Allograft rejection pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05320
Autoimmune thyroid disease pathway
mmu05340
Primary immunodeficiency pathway
mmu04672
Intestinal immune network for IgA production pathway
mmu05416
Viral myocarditis pathway
mmu05144
Malaria pathway
mmu05145
Toxoplasmosis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_213138
Immune System pathway
REACT_214469
Adaptive Immune System pathway
REACT_215390
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04660
T cell receptor signaling pathway pathway
hsa05330
Allograft rejection pathway
hsa05320
Autoimmune thyroid disease pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05340
Primary immunodeficiency pathway
hsa05310
Asthma pathway
hsa04672
Intestinal immune network for IgA production pathway
hsa05416
Viral myocarditis pathway
hsa05144
Malaria pathway
hsa05145
Toxoplasmosis pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
GPCR signaling pathway
PID NCI
cd40_pathway
CD40/CD40L signaling
tcrcalciumpathway
Calcium signaling in the CD4+ TCR pathway
integrin2_pathway
Beta2 integrin cell surface interactions
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt P27548
TrEMBL Q0VEI3
UniProt Splice Variant
Entrez Gene 21947
UniGene Mm.4861
RefSeq NM_011616
OMIM
CCDS CCDS30152
HPRD
IMGT
MGI ID MGI:88337
MGI Symbol Cd40lg
EMBL BC119225 CH466583 EU274582 S71858 S71861 X65453
GenPept AAC13639 AAC13640 AAI19226 ABX76043 CAA46448 EDL42166
RNA Seq Atlas 21947

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca