InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ULK1

Summary

InnateDB Gene

IDBG-631348.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ULK1

Gene Name

serine/threonine-protein kinase ULK1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012987

Encoded Proteins

IDBP-682983

unc-51-like kinase 1 (C. elegans)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25792739

[Homo sapiens] Stimulation of TMEM173-dependent IRF3 activation by ultraviolet radiation is due to apoptotic signalling-dependent disruption of ULK1, a pro-autophagic protein that negatively regulates TMEM173.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177169:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:46171844-46193233

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017268

ENSBTAP00000017268

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0017137	Rab GTPase binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006468	protein phosphorylation
GO:0007265	Ras protein signal transduction
GO:0007409	axonogenesis
GO:0008104	protein localization
GO:0009103	lipopolysaccharide biosynthetic process
GO:0010506	regulation of autophagy
GO:0010508	positive regulation of autophagy
GO:0016239	positive regulation of macroautophagy
GO:0021707	cerebellar granule cell differentiation
GO:0021933	radial glia guided migration of cerebellar granule cell
GO:0031175	neuron projection development
GO:0031623	receptor internalization
GO:0031669	cellular response to nutrient levels
GO:0042594	response to starvation
GO:0046777	protein autophosphorylation
GO:0048671	negative regulation of collateral sprouting
GO:0048675	axon extension
GO:0051386	regulation of neurotrophin TRK receptor signaling pathway

Cellular Component

GO:0000407	pre-autophagosomal structure
GO:0005737	cytoplasm
GO:0005776	autophagic vacuole
GO:0005829	cytosol
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0034045	pre-autophagosomal structure membrane
GO:0034273	ATG1/UKL1 signaling complex
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0070969	ULK1-ATG13-FIP200 complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000177169

View Gene Order

ENSMUSG00000029512

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04150

mTOR signaling pathway pathway

hsa04140

Regulation of autophagy pathway

mmu04140

Regulation of autophagy pathway

mmu04150

mTOR signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.1607

RefSeq

NM_001205927

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas