Bos taurus Gene: PSTPIP1 | |||||||||||||
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Summary | |||||||||||||
InnateDB Gene | IDBG-631349.3 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | PSTPIP1 | ||||||||||||
Gene Name | proline-serine-threonine phosphatase-interacting protein 1 | ||||||||||||
Synonyms | |||||||||||||
Species | Bos taurus | ||||||||||||
Ensembl Gene | ENSBTAG00000021144 | ||||||||||||
Encoded Proteins |
proline-serine-threonine phosphatase interacting protein 1
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Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||
Summary |
[Homo sapiens] Activates MEFV by binding to the B-Box domain of MEFV and unmasking its PYD domain
[Homo sapiens] Enhances binding of MEFV to PYCARD
[Homo sapiens] Tyrosine phosphorylation of PSTPIP1 significantly enhances its interaction with MEFV
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Entrez Gene | |||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140368:
The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 21:32644740-32689060 | ||||||||||||
Strand | Forward strand | ||||||||||||
Band | |||||||||||||
Transcripts |
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Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||
NETPATH |
TCR pathway
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REACTOME |
The NLRP3 inflammasome pathway
Inflammasomes pathway
Innate Immune System pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Immune System pathway
Innate Immune System pathway
Immune System pathway
The NLRP3 inflammasome pathway
Inflammasomes pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
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KEGG |
NOD-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
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INOH | |||||||||||||
PID NCI | |||||||||||||
Cross-References | |||||||||||||
SwissProt | |||||||||||||
TrEMBL | F1MZI1 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 513924 | ||||||||||||
UniGene | Bt.21819 | ||||||||||||
RefSeq | NM_001193040 XM_005221934 XM_005221935 | ||||||||||||
HUGO | HGNC:9580 | ||||||||||||
OMIM | |||||||||||||
CCDS | |||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | DAAA02052468 DAAA02052469 | ||||||||||||
GenPept | |||||||||||||
RNA Seq Atlas | 513924 | ||||||||||||