InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ESPL1

Summary

InnateDB Gene

IDBG-631353.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ESPL1

Gene Name

separin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008934

Encoded Proteins

IDBP-682885

extra spindle pole bodies homolog 1 (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135476:
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:26891701-26913470

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000011761

ENSBTAP00000011761

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000212	meiotic spindle organization
GO:0006508	proteolysis
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007127	meiosis I
GO:0045143	homologous chromosome segregation