InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ESPL1

Summary

InnateDB Gene

IDBG-36272.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ESPL1

Gene Name

extra spindle pole bodies homolog 1 (S. cerevisiae)

Synonyms

ESP1; SEPA

Species

Homo sapiens

Ensembl Gene

ENSG00000135476

Encoded Proteins

IDBP-36274

extra spindle pole bodies homolog 1 (S. cerevisiae)

IDBP-718173

IDBP-591175

extra spindle pole bodies homolog 1 (S. cerevisiae)

IDBP-589090

extra spindle pole bodies homolog 1 (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:53268299-53293643

Strand

Forward strand

Band

q13.13

Transcripts

ENST00000257934	ENSP00000257934
ENST00000553219	ENSP00000456450
ENST00000552671	ENSP00000447054
ENST00000552462	ENSP00000449831
ENST00000550026
ENST00000535123
ENST00000553016
ENST00000549154
ENST00000552600

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000212	meiotic spindle organization
GO:0000278	mitotic cell cycle
GO:0000910	cytokinesis
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007127	meiosis I
GO:0040001	establishment of mitotic spindle localization
GO:0045143	homologous chromosome segregation
GO:0045842	positive regulation of mitotic metaphase/anaphase transition
GO:0045875	negative regulation of sister chromatid cohesion

Cellular Component

GO:0005634	nucleus
GO:0005813	centrosome
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000058290

View Gene Order

ENSBTAG00000008934

Not yet available

Pathways

NETPATH

REACTOME

REACT_150471

Separation of Sister Chromatids pathway

REACT_115566

Cell Cycle pathway

REACT_910

M Phase pathway

REACT_1275

Mitotic Anaphase pathway

REACT_152

Cell Cycle, Mitotic pathway

REACT_150314

Mitotic Metaphase and Anaphase pathway

KEGG

hsa04110

Cell cycle pathway

hsa04114

Oocyte meiosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.153479

RefSeq

NM_012291 XM_006719705

HUGO

OMIM

CCDS

CCDS8852

HPRD

06825

IMGT

EMBL

GenPept

RNA Seq Atlas