Version 5.4
| Bos taurus Gene: FYN | |||||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-631420.3 | ||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | FYN | ||||||||||||||||||||||||||||||||||||||||
| Gene Name | Tyrosine-protein kinase Fyn | ||||||||||||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||||||||||||
| Species | Bos taurus | ||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSBTAG00000011851 | ||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
Tyrosine-protein kinase Fyn
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000010810:
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 9:39107807-39259883 | ||||||||||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||||||||||
| Band | |||||||||||||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 274 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||||
| REACTOME |
DAP12 interactions pathway
CD28 dependent PI3K/Akt signaling pathway
EPHA-mediated growth cone collapse pathway
Signaling by EGFR pathway
Cell surface interactions at the vascular wall pathway
GAB1 signalosome pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
NCAM signaling for neurite out-growth pathway
Regulation of signaling by CBL pathway
Signaling by PDGF pathway
Signaling by ERBB4 pathway
Costimulation by the CD28 family pathway
CD28 dependent Vav1 pathway pathway
CRMPs in Sema3A signaling pathway
DCC mediated attractive signaling pathway
Signaling by FGFR pathway
Cytokine Signaling in Immune system pathway
Netrin-1 signaling pathway
VEGFA-VEGFR2 Pathway pathway
Nephrin interactions pathway
Hemostasis pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
PI3K events in ERBB2 signaling pathway
Immune System pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Platelet activation, signaling and aggregation pathway
EPH-Ephrin signaling pathway
CD28 co-stimulation pathway
CTLA4 inhibitory signaling pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Signal Transduction pathway
GPVI-mediated activation cascade pathway
Cell-Cell communication pathway
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
Signaling by EGFR in Cancer pathway
Netrin mediated repulsion signals pathway
Ephrin signaling pathway
PI-3K cascade pathway
Axon guidance pathway
NGF signalling via TRKA from the plasma membrane pathway
FCGR activation pathway
Regulation of KIT signaling pathway
PI3K events in ERBB4 signaling pathway
Downstream signaling of activated FGFR pathway
EPH-ephrin mediated repulsion of cells pathway
Signalling by NGF pathway
Signaling by VEGF pathway
Platelet Adhesion to exposed collagen pathway
PI3K/AKT Signaling in Cancer pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Adaptive Immune System pathway
Downstream signal transduction pathway
PIP3 activates AKT signaling pathway
EPHB-mediated forward signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signaling by SCF-KIT pathway
Innate Immune System pathway
PI3K/AKT activation pathway
Signaling by Interleukins pathway
DAP12 signaling pathway
Disease pathway
Signaling by FGFR in disease pathway
Fc epsilon receptor (FCERI) signaling pathway
Semaphorin interactions pathway
Developmental Biology pathway
Sema3A PAK dependent Axon repulsion pathway
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| KEGG | |||||||||||||||||||||||||||||||||||||||||
| INOH | |||||||||||||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
EGFR1 pathway
KitReceptor pathway
TCR pathway
BCR pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL6 pathway
IL-7 pathway
RANKL pathway
Leptin pathway
TSLP pathway
FSH pathway
Prolactin pathway
IL11 pathway
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| REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
FCGR activation pathway
Regulation of signaling by CBL pathway
Interleukin-3, 5 and GM-CSF signaling pathway
CTLA4 inhibitory signaling pathway
CD28 dependent PI3K/Akt signaling pathway
CD28 dependent Vav1 pathway pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
PECAM1 interactions pathway
Cell surface interactions at the vascular wall pathway
Platelet Adhesion to exposed collagen pathway
GPVI-mediated activation cascade pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Regulation of KIT signaling pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Nef and signal transduction pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Nephrin interactions pathway
Netrin mediated repulsion signals pathway
DCC mediated attractive signaling pathway
Netrin-1 signaling pathway
CRMPs in Sema3A signaling pathway
Sema3A PAK dependent Axon repulsion pathway
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
NCAM signaling for neurite out-growth pathway
Signaling by FGFR in disease pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Cell-Cell communication pathway
Semaphorin interactions pathway
EPHB-mediated forward signaling pathway
Signaling by VEGF pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Adaptive Immune System pathway
Immune System pathway
Ephrin signaling pathway
EPHA-mediated growth cone collapse pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
EPH-ephrin mediated repulsion of cells pathway
HIV Infection pathway
EPH-Ephrin signaling pathway
PI3K/AKT Signaling in Cancer pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Host Interactions of HIV factors pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Hemostasis pathway
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
PI3K/AKT activation pathway
CD28 dependent PI3K/Akt signaling pathway
Disease pathway
Hemostasis pathway
Nephrin interactions pathway
Netrin-1 signaling pathway
Signaling by VEGF pathway
Regulation of KIT signaling pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Cytokine Signaling in Immune system pathway
EPHA-mediated growth cone collapse pathway
Sema3A PAK dependent Axon repulsion pathway
PIP3 activates AKT signaling pathway
Cell surface interactions at the vascular wall pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Platelet Adhesion to exposed collagen pathway
DCC mediated attractive signaling pathway
FCGR activation pathway
EPH-ephrin mediated repulsion of cells pathway
Signaling by EGFR pathway
GPVI-mediated activation cascade pathway
EPH-Ephrin signaling pathway
CD28 dependent Vav1 pathway pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
EPHB-mediated forward signaling pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Fc epsilon receptor (FCERI) signaling pathway
Signaling by Interleukins pathway
PI3K/AKT Signaling in Cancer pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
CTLA4 inhibitory signaling pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
Developmental Biology pathway
GAB1 signalosome pathway
Ephrin signaling pathway
Semaphorin interactions pathway
NGF signalling via TRKA from the plasma membrane pathway
Interleukin-3, 5 and GM-CSF signaling pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Signaling by FGFR pathway
CRMPs in Sema3A signaling pathway
Cell-Cell communication pathway
Signaling by EGFR in Cancer pathway
NCAM signaling for neurite out-growth pathway
Regulation of signaling by CBL pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
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| KEGG |
Pathogenic Escherichia coli infection pathway
Fc epsilon RI signaling pathway pathway
Axon guidance pathway
Adherens junction pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Prion diseases pathway
Viral myocarditis pathway
Osteoclast differentiation pathway
Axon guidance pathway
T cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Adherens junction pathway
Focal adhesion pathway
Prion diseases pathway
Viral myocarditis pathway
Osteoclast differentiation pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
B cell receptor signaling pathway
Integrin signaling pathway pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
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| PID NCI |
Nephrin/Neph1 signaling in the kidney podocyte
TCR signaling in naïve CD8+ T cells
IL2-mediated signaling events
Reelin signaling pathway
Netrin-mediated signaling events
ErbB4 signaling events
TCR signaling in naïve CD4+ T cells
Ephrin A reverse signaling
Syndecan-3-mediated signaling events
Angiopoietin receptor Tie2-mediated signaling
Signaling events mediated by VEGFR1 and VEGFR2
Fc-epsilon receptor I signaling in mast cells
E-cadherin signaling in keratinocytes
Posttranslational regulation of adherens junction stability and dissassembly
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| Cross-References | |||||||||||||||||||||||||||||||||||||||||
| SwissProt | A0JNB0 | ||||||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | 527263 | ||||||||||||||||||||||||||||||||||||||||
| UniGene | Bt.6838 | ||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_001077972 XM_005210788 | ||||||||||||||||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||
| CCDS | |||||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||
| EMBL | BC126591 | ||||||||||||||||||||||||||||||||||||||||
| GenPept | AAI26592 | ||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 527263 | ||||||||||||||||||||||||||||||||||||||||