Version 5.4
Bos taurus Gene: BT.69450
Summary
InnateDB Gene IDBG-631450.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.69450
Gene Name RNA/RNP complex-1-interacting phosphatase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000033255
Encoded Proteins
IDBP-682988
RNA/RNP complex-1-interacting phosphatase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000144048:
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:10836512-10852450
Strand Forward strand
Band
Transcripts
ENSBTAT00000047256 ENSBTAP00000044476
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004651 polynucleotide 5'-phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0044822 poly(A) RNA binding
GO:0098519 nucleotide phosphatase activity, acting on free nucleotides
Biological Process
GO:0006470 protein dephosphorylation
GO:0016070 RNA metabolic process
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0098507 polynucleotide 5' dephosphorylation
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000144048
View Gene Order
ENSMUSG00000030002
View Gene Order
Cross-References
SwissProt
TrEMBL E1BCH4
UniProt Splice Variant
Entrez Gene 786531
UniGene Bt.108016 Bt.13589 Bt.69450 Bt.87854
RefSeq NM_001014875 XM_001253405 XM_005193868 XM_005212513 XM_005212514
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02030350
GenPept
RNA Seq Atlas 508944 786531

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca