Version 5.4
Bos taurus Gene: SLC26A5
Summary
InnateDB Gene IDBG-631500.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC26A5
Gene Name prestin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009296
Encoded Proteins
IDBP-683041
solute carrier family 26, member 5 (prestin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170615:
This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:44826226-44862357
Strand Reverse strand
Band
Transcripts
ENSBTAT00000012245 ENSBTAP00000012245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0030507 spectrin binding
Biological Process
GO:0007605 sensory perception of sound
GO:0008272 sulfate transport
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
GO:1902358 sulfate transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000170615
View Gene Order
ENSMUSG00000029015
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.106111
RefSeq NM_001192878 XM_005205361
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca