Version 5.4
Homo sapiens Gene: SLC26A5
Summary
InnateDB Gene IDBG-34404.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC26A5
Gene Name solute carrier family 26, member 5 (prestin)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170615
Encoded Proteins
IDBP-34406
solute carrier family 26, member 5 (prestin)
IDBP-34408
solute carrier family 26, member 5 (prestin)
IDBP-34410
solute carrier family 26, member 5 (prestin)
IDBP-34412
solute carrier family 26, member 5 (prestin)
IDBP-243003
solute carrier family 26, member 5 (prestin)
IDBP-243007
solute carrier family 26, member 5 (prestin)
IDBP-243009
solute carrier family 26, member 5 (prestin)
IDBP-243011
solute carrier family 26, member 5 (prestin)
IDBP-243013
solute carrier family 26, member 5 (prestin)
IDBP-384692
solute carrier family 26, member 5 (prestin)
IDBP-384694
solute carrier family 26, member 5 (prestin)
IDBP-384695
solute carrier family 26, member 5 (prestin)
IDBP-384696
solute carrier family 26, member 5 (prestin)
IDBP-384697
solute carrier family 26, member 5 (prestin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:103352730-103446177
Strand Reverse strand
Band q22.1
Transcripts
ENST00000339444 ENSP00000342396
ENST00000356767 ENSP00000349210
ENST00000354356 ENSP00000346325
ENST00000306312 ENSP00000304783
ENST00000393735 ENSP00000377336
ENST00000393730 ENSP00000377331
ENST00000393729 ENSP00000377330
ENST00000393727 ENSP00000377328
ENST00000393723 ENSP00000377324
ENST00000454864 ENSP00000416502
ENST00000445809 ENSP00000396833
ENST00000432958 ENSP00000389733
ENST00000423416 ENSP00000389018
ENST00000456463 ENSP00000395568
ENST00000487407
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0030507 spectrin binding
Biological Process
GO:0007605 sensory perception of sound
GO:0008272 sulfate transport
GO:0008360 regulation of cell shape
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
GO:1902358 sulfate transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029015
View Gene Order
ENSBTAG00000009296
Not yet available
Cross-References
SwissProt
TrEMBL Q7Z7F4
UniProt Splice Variant
Entrez Gene 375611
UniGene Hs.585146
RefSeq NM_001167962 NM_198999 NM_206883 NM_206884 NM_206885 XM_006715976
HUGO HGNC:9359
OMIM 604943
CCDS CCDS43629 CCDS43630 CCDS55150 CCDS5732 CCDS5733
HPRD 09224
IMGT
EMBL AC004668 AC005064 AC093701 AY289133
GenPept AAP43685
RNA Seq Atlas 375611

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca