InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: VTN

Summary

InnateDB Gene

IDBG-631579.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VTN

Gene Name

vitronectin precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016151

Encoded Proteins

IDBP-683124

vitronectin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:20413683-20416614

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000021497

ENSBTAP00000021497

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0030247	polysaccharide binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0006955	immune response
GO:0007160	cell-matrix adhesion
GO:0010811	positive regulation of cell-substrate adhesion
GO:0010951	negative regulation of endopeptidase activity
GO:0014911	positive regulation of smooth muscle cell migration
GO:0030198	extracellular matrix organization
GO:0032092	positive regulation of protein binding
GO:0033627	cell adhesion mediated by integrin
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0061302	smooth muscle cell-matrix adhesion

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle