Version 5.4
Bos taurus Gene: SARM1
Summary
InnateDB Gene IDBG-631587.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SARM1
Gene Name sterile alpha and TIR motif-containing protein 1 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002816
Encoded Proteins
IDBP-683173
sterile alpha and TIR motif containing 1
IDBP-683181
sterile alpha and TIR motif containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 16964262
[Homo sapiens] Negatively regulates adaptor protein TICAM1-dependent Toll-like receptor signaling
PMID 23499490
[Mus musculus] Upon infection with encephalitic Bunyavirus, SARM1 is activated by RIG-I/MAVS signalling to mediate neuronal cell death.
PMID 23751821
[Mus musculus] Sarm1 is expressed in neurons and regulates the expression of inflammatory and anti-viral cytokines.
PMID 23749635
[Mus musculus] Sarm1 null mice are resistant to central nervous system infection with vesicular stomatitis virus.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000004139:
Gene Information
Type Protein coding
Genomic Location Chromosome 19:20419004-20441105
Strand Forward strand
Band
Transcripts
ENSBTAT00000003645 ENSBTAP00000003645
ENSBTAT00000053952 ENSBTAP00000049014
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0009749 response to glucose
GO:0042981 regulation of apoptotic process
GO:0048814 regulation of dendrite morphogenesis
GO:1901214 regulation of neuron death
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0030425 dendrite
GO:0031315 extrinsic component of mitochondrial outer membrane
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000004139
View Gene Order
ENSMUSG00000050132
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.44806
RefSeq NM_001102518
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca