Version 5.4
Homo sapiens Gene: SARM1
Summary
InnateDB Gene IDBG-36569.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SARM1
Gene Name sterile alpha and TIR motif containing 1
Synonyms MyD88-5; SAMD2; SARM
Species Homo sapiens
Ensembl Gene ENSG00000004139
Encoded Proteins
IDBP-759692
IDBP-763568
IDBP-761600
IDBP-810781
sterile alpha and TIR motif containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 16964262
Negatively regulates adaptor protein TICAM1-dependent Toll-like receptor signaling
InnateDB Annotation from Orthologs
Summary
PMID 23499490
[Mus musculus] Upon infection with encephalitic Bunyavirus, SARM1 is activated by RIG-I/MAVS signalling to mediate neuronal cell death.
PMID 23751821
[Mus musculus] Sarm1 is expressed in neurons and regulates the expression of inflammatory and anti-viral cytokines.
PMID 23749635
[Mus musculus] Sarm1 null mice are resistant to central nervous system infection with vesicular stomatitis virus.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:28364356-28404049
Strand Forward strand
Band q11.2
Transcripts
ENST00000379061
ENST00000577870
ENST00000580711
ENST00000579593 ENSP00000462228
ENST00000582323 ENSP00000464166
ENST00000578128 ENSP00000462479
ENST00000585482 ENSP00000468032
ENST00000585453
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0007165 signal transduction
GO:0009749 response to glucose
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0042981 regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0048814 regulation of dendrite morphogenesis
GO:1901214 regulation of neuron death
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0031315 extrinsic component of mitochondrial outer membrane
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050132
View Gene Order
ENSBTAG00000002816
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.743510
RefSeq NM_015077
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca