InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SPR

Summary

InnateDB Gene

IDBG-631591.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPR

Gene Name

Sepiapterin reductase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021961

Encoded Proteins

IDBP-683131

sepiapterin reductase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116096:
This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:11540747-11548873

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000029280

ENSBTAP00000029280

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004757	sepiapterin reductase activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0006558	L-phenylalanine metabolic process
GO:0006729	tetrahydrobiopterin biosynthetic process
GO:0006809	nitric oxide biosynthetic process
GO:0008152	metabolic process
GO:0016265	death
GO:0019889	pteridine metabolic process
GO:0040014	regulation of multicellular organism growth
GO:0042415	norepinephrine metabolic process
GO:0042417	dopamine metabolic process
GO:0042428	serotonin metabolic process
GO:0046146	tetrahydrobiopterin metabolic process
GO:0048667	cell morphogenesis involved in neuron differentiation
GO:0050882	voluntary musculoskeletal movement
GO:0055114	oxidation-reduction process