Version 5.4
Mus musculus Gene: Spr
Summary
InnateDB Gene IDBG-163013.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spr
Gene Name sepiapterin reductase
Synonyms AA409688; ENSMUSG00000071345; Gm10328
Species Mus musculus
Ensembl Gene ENSMUSG00000033735
Encoded Proteins
IDBP-163015
sepiapterin reductase
IDBP-620324
sepiapterin reductase
IDBP-620326
sepiapterin reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116096:
This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:85133678-85137766
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000045986 ENSMUSP00000048111
ENSMUST00000174769 ENSMUSP00000134379
ENSMUST00000174286 ENSMUSP00000133859
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004757 sepiapterin reductase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006558 L-phenylalanine metabolic process
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0006809 nitric oxide biosynthetic process
GO:0008152 metabolic process
GO:0016265 death
GO:0019889 pteridine metabolic process
GO:0040014 regulation of multicellular organism growth
GO:0042415 norepinephrine metabolic process
GO:0042417 dopamine metabolic process
GO:0042428 serotonin metabolic process
GO:0046146 tetrahydrobiopterin metabolic process
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050882 voluntary musculoskeletal movement
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000116096
View Gene Order
ENSBTAG00000021961
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00790
Folate biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111176
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
REACT_12389
eNOS activation and regulation pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_111217
Metabolism pathway
REACT_226352
eNOS activation and regulation pathway
REACT_220341
Metabolism of nitric oxide pathway
REACT_219139
Metabolism pathway
REACT_217517
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation pathway
KEGG
hsa00790
Folate biosynthesis pathway
INOH
INOH website
Folate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28393
RefSeq NM_011467
OMIM
CCDS CCDS51826
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca