Version 5.4
Bos taurus Gene: TOX3
Summary
InnateDB Gene IDBG-631674.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOX3
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000418
Encoded Proteins
IDBP-683235
TOX high mobility group box family member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103460:
The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:21000513-21120358
Strand Reverse strand
Band
Transcripts
ENSBTAT00000000539 ENSBTAP00000000539
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0034056 estrogen response element binding
GO:0042803 protein homodimerization activity
GO:0051219 phosphoprotein binding
Biological Process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000103460
View Gene Order
ENSMUSG00000043668
View Gene Order
Cross-References
SwissProt
TrEMBL E1BKT2
UniProt Splice Variant
Entrez Gene 539135
UniGene
RefSeq XM_002694777 XM_005195209 XM_005195210 XM_005218800 XM_005218801 XM_880075
HUGO HGNC:11972
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02046427 DAAA02046428 DAAA02046429 DAAA02046430
GenPept
RNA Seq Atlas 539135

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca