InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LMNA

Summary

InnateDB Gene

IDBG-631682.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LMNA

Gene Name

prelamin-A/C

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017574

Encoded Proteins

IDBP-683248

lamin A/C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160789:
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:14696144-14715262

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023373

ENSBTAP00000023373

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 111 interaction(s) predicted by orthology.

Predicted by orthology
Total	111 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0006997	nucleus organization
GO:0006998	nuclear envelope organization
GO:0007517	muscle organ development
GO:0030334	regulation of cell migration
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity
GO:0034504	protein localization to nucleus
GO:0035105	sterol regulatory element binding protein import into nucleus
GO:0055015	ventricular cardiac muscle cell development
GO:0071456	cellular response to hypoxia
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:0090343	positive regulation of cell aging
GO:1900180	regulation of protein localization to nucleus
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005638	lamin filament
GO:0005737	cytoplasm
GO:0005882	intermediate filament
GO:0048471	perinuclear region of cytoplasm