Version 5.4
Homo sapiens Gene: TPM2
Summary
InnateDB Gene IDBG-63176.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPM2
Gene Name tropomyosin 2 (beta)
Synonyms AMCD1; DA1; DA2B; HEL-S-273; NEM4; TMSB
Species Homo sapiens
Ensembl Gene ENSG00000198467
Encoded Proteins
IDBP-63180
tropomyosin 2 (beta)
IDBP-63182
tropomyosin 2 (beta)
IDBP-63184
tropomyosin 2 (beta)
IDBP-63186
tropomyosin 2 (beta)
IDBP-810426
tropomyosin 2 (beta)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:35681992-35691020
Strand Reverse strand
Band p13.3
Transcripts
ENST00000378300 ENSP00000367550
ENST00000378292 ENSP00000367542
ENST00000329305 ENSP00000367541
ENST00000360958 ENSP00000354219
ENST00000471212
ENST00000486018
ENST00000607559 ENSP00000475952
ENST00000604975
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 39 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
Biological Process
GO:0006936 muscle contraction
GO:0030049 muscle filament sliding
GO:0043462 regulation of ATPase activity
Cellular Component
GO:0005829 cytosol
GO:0005862 muscle thin filament tropomyosin
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000028464
View Gene Order
Pathways
NETPATH
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001301226 NM_001301227 NM_003289 NM_213674 XM_005251568 XM_005251569
HUGO
OMIM
CCDS CCDS6586 CCDS6587
HPRD 11768
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca