Version 5.4
Mus musculus Gene: Tpm2
Summary
InnateDB Gene IDBG-141434.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tpm2
Gene Name tropomyosin 2, beta
Synonyms Tpm-2; Trop-2
Species Mus musculus
Ensembl Gene ENSMUSG00000028464
Encoded Proteins
IDBP-141438
tropomyosin 2, beta
IDBP-265661
tropomyosin 2, beta
IDBP-265663
tropomyosin 2, beta
IDBP-540423
tropomyosin 2, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the tropomyosin family which encodes proteins that bind to actin filaments and stabilize them by regulating access to actin modifying proteins. The encoded protein is a high molecular weight tropomyosin expressed in slow skeletal muscle. In humans, mutations in this gene are associated with nemaline myopathy, cap disease and distal arthrogryposis syndromes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:43514711-43523765
Strand Reverse strand
Band A5
Transcripts
ENSMUST00000030184 ENSMUSP00000030184
ENSMUST00000107914 ENSMUSP00000103547
ENSMUST00000107913 ENSMUSP00000103546
ENSMUST00000150262
ENSMUST00000133355
ENSMUST00000150592 ENSMUSP00000119908
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
Biological Process
GO:0006936 muscle contraction
GO:0043462 regulation of ATPase activity
Cellular Component
GO:0005862 muscle thin filament tropomyosin
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000198467
View Gene Order
Pathways
NETPATH
REACTOME
REACT_232053
Striated Muscle Contraction pathway
REACT_235059
Smooth Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
KEGG
mmu04260
Cardiac muscle contraction pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.646
RefSeq NM_001277875 NM_001277876 NM_009416 XM_006537780
OMIM
CCDS CCDS18100 CCDS71374
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca