InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.91277

Summary

InnateDB Gene

IDBG-631881.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.91277

Gene Name

DNA polymerase eta

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006015

Encoded Proteins

IDBP-683457

DNA polymerase eta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170734:
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:17092572-17115947

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007900

ENSBTAP00000007900

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding

Biological Process

GO:0000731	DNA synthesis involved in DNA repair
GO:0006261	DNA-dependent DNA replication
GO:0006281	DNA repair
GO:0006290	pyrimidine dimer repair
GO:0006301	postreplication repair
GO:0010225	response to UV-C